Understanding Coronary Vasospasm

(A reversible cause of chest pain and reduced blood flow to the heart)

What is Coronary Vasospasm?

Coronary vasospasm, also called Prinzmetal’s angina or variant angina, occurs when a coronary artery suddenly tightens or spasms, narrowing the vessel and reducing blood flow to the heart.

Unlike a typical heart attack caused by plaque buildup or a blood clot, vasospasm results from abnormal contraction of the artery’s muscle. These episodes are often transient and reversible.

Who Gets Coronary Vasospasm?

Coronary vasospasm can affect people with or without coronary artery disease, but it is more commonly seen in:

Women, especially under age 60

People who smoke

Individuals with migraines, Raynaud’s phenomenon, or other vascular disorders

Those experiencing emotional or physical stress

Symptoms of Coronary Vasospasm

It can occur in people with or without coronary artery disease, but it’s more common in:

Chest pain (angina) at rest, often in the early morning or at night
Chest tightness, pressure, or burning sensation
Shortness of breath, palpitations, or fainting (in severe cases)
Pain that can resolve spontaneously or with nitroglycerin

CMD often causes angina-like symptoms, but tests for blockages may come back “normal,” which can delay diagnosis.

How is it Diagnosed?

Since vasospasm may not show up during routine testing, diagnosis may involve:

Electrocardiogram (EKG) during an episode, showing temporary changes

Coronary angiography with a provocative test (e.g., with acetylcholine or ergonovine)

Ruling out fixed blockages with imaging

How is it Treated?

The goal is to prevent spasms and relieve symptoms:

Lifestyle Changes

Stop smoking and avoid secondhand smoke

Manage stress and avoid triggers (e.g., cold exposure, certain drugs)

Limit alcohol and stimulant use (like cocaine, amphetamines)

Medications

Calcium channel blockers (CCBs): main treatment to prevent spasm

Long-acting nitrates: help keep vessels open

Short-acting nitroglycerin: for relief during an episode

Statins if there’s underlying disease

Beta-blockers are usually avoided in pure vasospasm, as they may worsen symptoms in some patients.

Takeaway

Coronary vasospasm is a reversible and treatable cause of chest pain. If you experience chest pain at rest, especially at night or early morning, schedule a consultation with our team to evaluate for vasospastic angina. With proper treatment and lifestyle changes, symptoms can usually be controlled and heart health protected.

Dr. Simona Campa
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